MIT-HOL kerdes [2564]: Kemia

[Fazekas Andrea]

Kedves kerdezo!

A thiomersal (helyette inkabb a Thimerosal nevet hasznaljak) egy =
altalanos
fertotlenitoszer pl. vakcinakban is hasznaljak. A MEDLINE-ban
http://www.ncbi.nlm.nih.gov/PubMed/ keresve eleg sok cikk szol a =
thimerosal
okozta allergiarol. (A Medline-ban az allergy es a hypersensitivity
kifejezeseket erdemes keresni.) Nem neztem at az osszes cikket, de =
talaltam
egyet, amely talan valasz a kerdesere.

TI:    Mechanisms of drug-induced allergic contact dermatitis.=20
AU:    Lebrec-H; Bachot-N; Gaspard-I; Kerdine-S; Guinnepain-MT; =
Laurent-J;
Pallardy-M=20
AD:    INSERM U 461, Faculte de Pharmacie Paris Sud, Chatenay-Malabry,
France. hlebrec at infobiogen.fr=20
SO:    Cell-Biol-Toxicol. 1999 Feb; 15(1): 57-62=20
LA:    ENGLISH=20
AB:    Allergic contact dermatitis is induced by a wide variety of =
drugs
that trigger specific immune responses following topical exposure.
Identified chemical structures involved in such reactions include the=20
mercuric and thiosalicylic acid groups of thimerosal, the =
diphenylketone=20
group of the anti-inflammatory drug ketoprofen, the amide or ester=20
structure of local anesthetics, and the side-chain and thiazolidine =
ring=20
of beta-lactams. The T cell responses to such compounds involve CD4+ =
and=20
CD8+ alphabeta+ T lymphocytes and also CD4 /CD8 gammadelta+ T cells.=20
Although "T helper 2" cytokine production by drug-specific human T =
cells=20
from patients with allergic contact dermatitis has been described, T =
helper=20
1-like and T cytotoxic 1-like responses clearly play key roles in this=20
cutaneous reaction.=20

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Az Internet-konyvtaros

>Eletkor:
>Hely:
>Nyelv:
>Forras:
>Kerdes: Szeretn=E9m megk=E9rdezni, hogy akin=E9l a Thiomersal =
allergi=E1t mutattak
ki, (etil-higany->tioszalicilsav-Na)konkr=E9tan mely k=E9miaia =
anyagokra
allergi=E1s.
>K=F6sz=F6nettel
>Miert:
>Hol kereste: